Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | the low desulfurase activity is caused by the modification of IscS rather than by the formation of FeS in the solution | Escherichia coli | |
additional information | desulfurase activity is gradually inhibited as the amount of iron and sulfide bound to IscS increases. When 2Fe-2S binds IscS, about 20% of the activity is inhibited, when 8Fe-8S adheres to IscS, about 70% of the activity is inhibited. Thus, the cell is able to modulate its desulfurase activity with the formation of an IscS-iron-sulfide complex | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | iron alone or iron together with sulfide binds to IscS to make IscS-iron or IscS-iron-sulfide complexes. The formation of such complexes allows the activity of IscS to be modulated effectively | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
recombinat enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cysteine + ? | in the presence of cysteine, IscSs ability to bind iron improves significantly | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cysteine desulfurase | - |
Escherichia coli |
IscS | - |
Escherichia coli |