Inhibitors | Comment | Organism | Structure |
---|---|---|---|
interferon-gamma | downregulation of cysteine desulfurase and its protein partner IscU at both mRNA and protein level by stimulation of macrophages with interferon-gamma; the cysteine desulfurase Nfs1 and its scaffold protein partner IscU are down-regulated at both mRNA and protein levels when murine macrophages are physiologically stimulated with interferon-gamma | Mus musculus | |
lipopolysaccharide | downregulation of enzyme at both mRNA and protein level by stimulation of macrophages with lipopolysaccharide. Lipopolysaccharide triggers a delayed decline of cysteine desulfurase protein and its protein partner IscU; LPS triggers a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability, also the expression of IscU is down-regulated in LPS-stimulated macrophages | Mus musculus | |
additional information | exposure of cells to exogenous sources of NO does not alter Nfs1 expression; exposure of macrophages to exogenous sources of nitric oxide does not alter enzyme expression | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | enzyme isoform Nfs1 | Mus musculus | - |
macrophage | mitochondrial isoform of Nfs1 | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cysteine desulfurase | - |
Mus musculus |
Nfs1 | - |
Mus musculus |