Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | - |
Mus musculus | 5759 | - |
mitochondrial matrix | - |
Homo sapiens | 5759 | - |
mitochondrial matrix | - |
Saccharomyces cerevisiae | 5759 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cysteine + [enzyme]-cysteine | Escherichia coli | - |
L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | Azotobacter vinelandii | - |
L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | Synechocystis sp. | - |
L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | Synechocystis sp. PCC6714 | - |
L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
additional information | Saccharomyces cerevisiae | - |
? | - |
? | |
additional information | Azotobacter vinelandii | enzyme catalyzes the formation of Fe-S clusters in a component protein of nitrogenase in the presence of cysteine and ferrous iron in vitro | ? | - |
? | |
additional information | Haemophilus influenzae | isc genes are involved in the formation of Fe-S clusters in various Fe-S proteins | ? | - |
? | |
additional information | Escherichia coli | isc genes are involved in the formation of Fe-S clusters in various Fe-S proteins | ? | - |
? | |
additional information | Pseudomonas aeruginosa | isc genes are involved in the formation of Fe-S clusters in various Fe-S proteins | ? | - |
? | |
additional information | Escherichia coli | enzyme is involved in selenoprotein biosynthesis | ? | - |
? | |
additional information | Azotobacter vinelandii | enzyme is involved in selenoprotein biosynthesis | ? | - |
? | |
additional information | Escherichia coli | involved in thiamine biosynthesis, molybdopterin biosynthesis and tRNA modification | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Azotobacter vinelandii | - |
- |
- |
Escherichia coli | - |
- |
- |
Haemophilus influenzae | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Synechocystis sp. | - |
PCC6714 | - |
Synechocystis sp. PCC6714 | - |
PCC6714 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor | mechanism | Escherichia coli | |
L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor | mechanism | Azotobacter vinelandii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-cysteine | unlike other cysteine desulfurases the L-cysteine C-S-lyase from Synechocystis does not have a conserved cysteine residue at the active site | Synechocystis sp. | L-alanine + sulfide | - |
? | |
L-cysteine | unlike other cysteine desulfurases the L-cysteine C-S-lyase from Synechocystis does not have a conserved cysteine residue at the active site | Synechocystis sp. PCC6714 | L-alanine + sulfide | - |
? | |
L-cysteine + [enzyme]-cysteine | - |
Escherichia coli | L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | - |
Azotobacter vinelandii | L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | - |
Synechocystis sp. | L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | catalyzes the conversion of cysteine to alanine and sulfane sulfur via the formation of a protein-bound cysteine persulfide intermediate on a conserved cysteine residue | Azotobacter vinelandii | L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | iscS has cysteine desulfurase activity and mobilizes sulfur from cysteine for the repair of the [4Fe-4S] cluster in apo-dihydroxyacid dehydratase | Escherichia coli | L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-cysteine + [enzyme]-cysteine | - |
Synechocystis sp. PCC6714 | L-alanine + [enzyme]-S-sulfanylcysteine | - |
? | |
L-selenocysteine | - |
Escherichia coli | L-alanine + selenium | - |
? | |
L-selenocysteine | - |
Azotobacter vinelandii | L-alanine + selenium | - |
? | |
L-selenocysteine | - |
Synechocystis sp. | L-alanine + selenium | - |
? | |
L-selenocysteine | - |
Synechocystis sp. PCC6714 | L-alanine + selenium | - |
? | |
additional information | - |
Saccharomyces cerevisiae | ? | - |
? | |
additional information | enzyme catalyzes the formation of Fe-S clusters in a component protein of nitrogenase in the presence of cysteine and ferrous iron in vitro | Azotobacter vinelandii | ? | - |
? | |
additional information | isc genes are involved in the formation of Fe-S clusters in various Fe-S proteins | Haemophilus influenzae | ? | - |
? | |
additional information | isc genes are involved in the formation of Fe-S clusters in various Fe-S proteins | Escherichia coli | ? | - |
? | |
additional information | isc genes are involved in the formation of Fe-S clusters in various Fe-S proteins | Pseudomonas aeruginosa | ? | - |
? | |
additional information | enzyme is involved in selenoprotein biosynthesis | Escherichia coli | ? | - |
? | |
additional information | enzyme is involved in selenoprotein biosynthesis | Azotobacter vinelandii | ? | - |
? | |
additional information | involved in thiamine biosynthesis, molybdopterin biosynthesis and tRNA modification | Escherichia coli | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Escherichia coli | |
pyridoxal 5'-phosphate | - |
Azotobacter vinelandii |