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Literature summary for 2.8.1.6 extracted from

  • Bockman, M.R.; Engelhart, C.A.; Cramer, J.D.; Howe, M.D.; Mishra, N.K.; Zimmerman, M.; Larson, P.; Alvarez-Cabrera, N.; Park, S.W.; Boshoff, H.I.M.; Bean, J.M.; Young, V.G.; Ferguson, D.M.; Dartois, V.; Jarrett, J.T.; Schnappinger, D.; Aldrich, C.C.
    Investigation of ( S)-(-)-acidomycin a selective antimycobacterial natural product that inhibits biotin synthase (2019), ACS Infect. Dis., 5, 598-617 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
acidomycin acidomycin inhibits biotin synthesis through the competitive inhibition of biotin synthase BioB and also stimulates unproductive cleavage of S-adenosyl-L-methionine to generate the toxic metabolite 5'-deoxyadenosine. Acidomycin selectively accumulates in Mycobycterium tuberculosis. The development of spontaneous resistance by Mycobacterium tuberculosis to acidomycin is difficult, and only low-level resistance to acidomycin is observed by overexpression of BioB Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPQ7
-
-
Mycobacterium tuberculosis H37Rv P9WPQ7
-
-

Synonyms

Synonyms Comment Organism
BioB
-
 Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
 acidomycin approximate value, pH 8.0, 37°C Mycobacterium tuberculosis