Cloned (Comment) | Organism |
---|---|
transient transfection of human embryonic kidney HEK 293-F cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
C247S | site-directed mutagenesis, transient transfection of human embryonic kidney HEK 293-F cells, mutant completely lose the activity to metabolize 3-mercaptopyruvate that is assessed by measuring its products either pyruvate or H2S, the levels of bound sulfane sulfur are not increased | Mus musculus |
R187G | site-directed mutagenesis, transient transfection of human embryonic kidney HEK 293-F cells, mutant, which greatly lose the activity, decreases the levels of bound sulfane sulfur, but not statistically significant, no H2S production | Mus musculus |
R196G | site-directed mutagenesis, transient transfection of human embryonic kidney HEK 293-F cells, mutant, which partially lose the activity, does not decrease the levels of bound sulfane sulfur, no H2S production | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-mercaptopyruvate + cyanide | Mus musculus | H2S is produced by 3-mercaptopyruvate sulfurtransferase with cysteine aminotransferase in the presence of cysteine and alpha-ketoglutarate, supporting the existence of 3-mercaptopyruvate which has not been identified. Mercaptopyruvate can be provided by the metabolism of cysteine and alpha-ketoglutarate by cysteine aminotransferase (CAT) | H2S + ? | a major source of H2S production in the brain is from the enzyme 3-mercaptopyruvate sulfurtransferase | ? | |
additional information | Mus musculus | 3-mercaptopyruvate sulfurtransferase produces bound sulfane sulfur | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q99J99 | expression in human embryonic kidney HEK 293-F cells | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-mercaptopyruvate + cyanide | H2S is produced by 3-mercaptopyruvate sulfurtransferase with cysteine aminotransferase in the presence of cysteine and alpha-ketoglutarate, supporting the existence of 3-mercaptopyruvate which has not been identified. Mercaptopyruvate can be provided by the metabolism of cysteine and alpha-ketoglutarate by cysteine aminotransferase (CAT) | Mus musculus | H2S + ? | a major source of H2S production in the brain is from the enzyme 3-mercaptopyruvate sulfurtransferase | ? | |
additional information | 3-mercaptopyruvate sulfurtransferase produces bound sulfane sulfur | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-mercaptopyruvate sulfurtransferase | - |
Mus musculus |
3MST | - |
Mus musculus |