Literature summary for 2.8.1.2 extracted from

Alphey, M.S.; Williams, R.A.; Mottram, J.C.; Coombs, G.H.; Hunter, W.N.
The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase. A three-domain architecture with a serine protease-like triad at the active site (2003), J. Biol. Chem., 278, 48219-48227.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method	Leishmania major

Inhibitors

Inhibitors	Comment	Organism	Structure
N-alpha-4-tosyl-L-lysine chloromethyl ketone	interferes with Ser-255, 50% inhibition at 0.044 mM	Leishmania major
phenylmethanesulfonyl chloride	50% inhibition at 0.7 mM	Leishmania major

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3-mercaptopyruvate + cyanide	Leishmania major	-	pyruvate + thiocyanate	-	?

Organism

Organism	UniProt	Comment	Textmining
Leishmania major	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-mercaptopyruvate + cyanide	-	Leishmania major	pyruvate + thiocyanate	-	?

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Release 2023.1 (January 2023)