Literature summary for 2.8.1.10 extracted from

Chatterjee, A.; Abeydeera, N.D.; Bale, S.; Pai, P.J.; Dorrestein, P.C.; Russell, D.H.; Ealick, S.E.; Begley, T.P.
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase (2011), Nature, 478, 542-546.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
34991	-	x * 34991, calculated	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P32318	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	THI4 is a suicide enzyme serving as a cosubstrate rather than an enzyme for the formation of the thiazole moiety of thiamine. This assembly involves a complex reaction sequence in which NAD serves as the source of the five-carbon chain and THI4 serves as the sulfur source	Saccharomyces cerevisiae	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 34991, calculated	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)