Literature summary for 2.8.1.10 extracted from

Hazra, A.B.; Han, Y.; Chatterjee, A.; Zhang, Y.; Lai, R.Y.; Ealick, S.E.; Begley, T.P.
A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase (2011), J. Am. Chem. Soc., 133, 9311-9319.

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Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	O31618	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS]	-	Bacillus subtilis	2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O	-	?

Synonyms

Synonyms	Comment	Organism
ThiG	-	Bacillus subtilis

General Information

General Information	Comment	Organism
physiological function	reaction product of ThiG is a thiazole tautomer (R,Z)-2-(2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate, which is aromatized by tautomerase TenI to yield 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate	Bacillus subtilis

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Release 2023.1 (January 2023)