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Literature summary for 2.8.1.1 extracted from

  • Meza, A.; Cambui, C.; Moreno, A.; Fessel, M.; Balan, A.
    Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells (2019), Sci. Rep., 9, 16791 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine CysA2 interacts with pulmonary cells, and it is capable to activate macrophages and dendritic cells Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of CysA2 at 2.29 A shows two alpha/beta domains. The N domain is inactive, whereas the C domain is responsible for the catalytic activity. The conserved catalytic cysteine of the active site is Cys233 Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.66
-
cyanide pH 8.0, 37°C Mycobacterium tuberculosis
2.89
-
thiosulfate pH 8.0, 37°C Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74000
-
gel filtratioin Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WHF9 cf. EC 2.8.1.2
-
Mycobacterium tuberculosis H37Rv P9WHF9 cf. EC 2.8.1.2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-mercaptopyruvate + cyanide
-
Mycobacterium tuberculosis pyruvate + thiocyanate
-
?
3-mercaptopyruvate + cyanide
-
Mycobacterium tuberculosis H37Rv pyruvate + thiocyanate
-
?
thiosulfate + cyanide
-
Mycobacterium tuberculosis sulfite + thiocyanate
-
?
thiosulfate + cyanide
-
Mycobacterium tuberculosis H37Rv sulfite + thiocyanate
-
?

Subunits

Subunits Comment Organism
dimer 2 * 31015, calculated from sequence Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
CysA2
-
Mycobacterium tuberculosis
Rv0815
-
Mycobacterium tuberculosis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
58.3
-
melting temperature Mycobacterium tuberculosis