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Literature summary for 2.8.1.1 extracted from

  • de Paula, C.P.; Dos Santos, M.C.; Tairum, C.A.; Breyer, C.A.; Toledo-Silva, G.; Toyama, M.H.; Mori, G.M.; de Oliveira, M.A.
    Glutaredoxin-like protein (GLP)-a novel bacteria sulfurtransferase that protects cells against cyanide and oxidative stresses (2020), Appl. Microbiol. Biotechnol., 104, 5477-5492 .
    View publication on PubMed
Search for more literature for 2.8.1.1

Protein Variants

Protein Variants Comment Organism
C266S activity is completely abolished, similar to wild-type, mutant is able to form high molecular weight oligomers (> 600 kDa) Xylella fastidiosa
C33S about 3fold increase in sulfurtransferase activity, mutation destabilizes the quaternary structure Xylella fastidiosa

Organism

Organism UniProt Comment Textmining
Xylella fastidiosa
-
-
-
Xylella fastidiosa 9a5c
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thiosulfate + cyanide
-
 Xylella fastidiosa sulfite + thiocyanate
-
 ?
thiosulfate + cyanide
-
 Xylella fastidiosa 9a5c sulfite + thiocyanate
-
 ?
thiosulfate + dithiothreitol
-
 Xylella fastidiosa ?
-
 ?
thiosulfate + dithiothreitol
-
 Xylella fastidiosa 9a5c ?
-
 ?
thiosulfate + glutathione
-
 Xylella fastidiosa ?
-
 ?
thiosulfate + glutathione
-
 Xylella fastidiosa 9a5c ?
-
 ?

Synonyms

Synonyms Comment Organism
GLP
-
 Xylella fastidiosa
glutaredoxin-like protein
-
 Xylella fastidiosa
XF_2394
-
 Xylella fastidiosa

Cofactor

Cofactor Comment Organism Structure
Fe-S center protein contains an Fe-S cluster Xylella fastidiosa

General Information

General Information Comment Organism
physiological function GLP can detoxify cyanide and transfer inorganic sulfur to acceptor molecules in vitro. The biological activity of GLP relies on the cysteine residues in the Grx and thiosulfate sulfurtransferase/rhodanese domain (Cys33 and Cys266, respectively). Expression of GLP in Escherichia coli can protect bacteria against high concentrations of cyanide and hydrogen peroxide Xylella fastidiosa