Literature summary for 2.8.1.1 extracted from

Morton, N.M.; Beltram, J.; Carter, R.N.; Michailidou, Z.; Gorjanc, G.; McFadden, C.; Barrios-Llerena, M.E.; Rodriguez-Cuenca, S.; Gibbins, M.T.; Aird, R.E.; Moreno-Navarrete, J.M.; Munger, S.C.; Svenson, K.L.; Gastaldello, A.; Ramage, L.; Naredo, G.; Zeyda, M.; Wang, Z.V.; Howie, A.F.; Saari, A.; Sipila, P.
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness (2016), Nat. Med., 22, 771-779.

Application

Application	Comment	Organism
medicine	enzyme mRNA expression in adipose tissue correlates positively with insulin sensitivity in adipose tissue and negatively with fat mass. Genetic enzyme identification as a beneficial regulator of adipocyte mitochondrial function has therapeutic significance for individuals with type 2 diabetes	Mus musculus

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
thiosulfate + cyanide	Mus musculus	-	sulfite + thiocyanate	-	?

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue	Comment	Organism	Textmining
adipocyte	-	Mus musculus	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thiosulfate + cyanide	-	Mus musculus	sulfite + thiocyanate	-	?

Synonyms	Comment	Organism
rhodanese	-	Mus musculus
TST	-	Mus musculus

General Information	Comment	Organism
malfunction	enzyme-deficient mice show markedly exacerbated diabetes	Mus musculus
physiological function	enzyme overexpression in adipocytes protects mice from diet-induced obesity and insulin-resistant diabetes	Mus musculus