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Literature summary for 2.7.8.7 extracted from

  • Wiemann, P.; Albermann, S.; Niehaus, E.M.; Studt, L.; von Bargen, K.W.; Brock, N.L.; Humpf, H.U.; Dickschat, J.S.; Tudzynski, B.
    The Sfp-type 4-phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity (2012), PLoS ONE, 7, e37519.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Fusarium fujikuroi

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Fusarium fujikuroi 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Fusarium fujikuroi

Organism

Organism UniProt Comment Textmining
Fusarium fujikuroi
-
-
-
Fusarium fujikuroi IMI58289
-
-
-

Synonyms

Synonyms Comment Organism
4-phosphopantetheinyl transferase
-
 Fusarium fujikuroi
PPT1
-
 Fusarium fujikuroi
PPTase
-
 Fusarium fujikuroi

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine
-
 Fusarium fujikuroi

General Information

General Information Comment Organism
malfunction deletion of the ppt1 gene results in loss of polyketide synthase- and polyketide synthase/non-ribosomal peptide synthase-derived products and in transcriptional down-regulation of distinct secondary metabolite cluster genes Fusarium fujikuroi
metabolism isoform Ppt1 is essentially involved in lysine biosynthesis and production of bikaverins, fusarubins and fusarins, but not moniliformin Fusarium fujikuroi
physiological function isoform Ppt1 is involved in conidiation and sexual mating recognition. Isoform Ppt1 contributes to a functional iron uptake system that is controlled by the GATA-type transcription factor Sre1. Isoform Ppt1 is a pathogenicity factor in hydroponic rice cultures Fusarium fujikuroi