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Literature summary for 2.7.8.41 extracted from

  • Sandoval-Calderon, M.; Geiger, O.; Guan, Z.; Barona-Gomez. F.; Sohlenkamp, C.
    A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria (2009), J. Biol. Chem., 284, 17383-17390.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.41

Cloned(Commentary)

Cloned (Comment) Organism
expression of Sco1389 in a cardiolipin-deficient Rhizobium etli mutant Streptomyces coelicolor

Inhibitors

Inhibitors Comment Organism Structure
EDTA 20 mM, loss of activity Streptomyces coelicolor

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ the enzyme is dependent on the presence of bivalent cations. The largest activity is found with Co2+, whereas Mn2+ supports a lower activity. No detectable cardiolipin synthase activity when using Ni2+, Ca2+, or Mg2+ Streptomyces coelicolor
Mn2+ the enzyme is dependent on the presence of bivalent cations. The largest activity is found with Co2+, whereas Mn2+ supports a lower activity. No detectable cardiolipin synthase activity when using Ni2+, Ca2+, or Mg2+ Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a CDP-diacylglycerol + a phosphatidylglycerol Streptomyces coelicolor
-
 a cardiolipin + CMP
-
 ?
a CDP-diacylglycerol + a phosphatidylglycerol Streptomyces coelicolor A3(2)
-
 a cardiolipin + CMP
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor Q9KZP3
-
-
Streptomyces coelicolor A3(2) Q9KZP3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a CDP-diacylglycerol + a phosphatidylglycerol
-
 Streptomyces coelicolor a cardiolipin + CMP
-
 ?
a CDP-diacylglycerol + a phosphatidylglycerol
-
 Streptomyces coelicolor A3(2) a cardiolipin + CMP
-
 ?

Synonyms

Synonyms Comment Organism
Sco1389
-
 Streptomyces coelicolor

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Streptomyces coelicolor

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5 pH 6.5: aboput 40% of maximal activity, pH 8.5: about 60%& of maximal activity Streptomyces coelicolor