Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.8.29 extracted from

  • Yu, A.; McMaster, C.R.; Byers, D.M.; Ridgway, N.D.; Cook, H.W.
    Resistance to UV-induced apoptosis in Chinese-hamster ovary cells overexpressing phosphatidylserine synthases (2004), Biochem. J., 381, 609-618.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphatidylserine biosynthesis in Chinese hamster ovary cells increases 2.5fold during UV-induced apoptosis. When cells are exposed to UV light to induce apoptosis, phosphatidylserine biosynthesis is stimulated 2fold in PSS II-expressing cells Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus O08888
-
-

Synonyms

Synonyms Comment Organism
PSSII
-
Cricetulus griseus

General Information

General Information Comment Organism
physiological function phosphatidylserine biosynthesis in Chinese hamster ovary cells increases 2.5fold during UV-induced apoptosis and is not reversed by caspase inhibitor, Z-VAD-FMK, i.e. benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone. Stimulation of synthesis is less specific for phosphatidylserine as similar levels of stimulation are observed for sphingomyelin biosynthesis. PSS I- , EC 2.7.8.8, or PSS II-expressing cells have higher basal levels of phosphatidylserine biosynthesis compared with vector control cells. When cells are exposed to UV light to induce apoptosis, phosphatidylserine biosynthesis is further stimulated 1.5- and 2fold in PSS I- and PSS II-expressing cells respectively. Cells overexpressing PSS I and II are actually resistant to UV-induced apoptosis Cricetulus griseus