Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphatidylserine biosynthesis in Chinese hamster ovary cells increases 2.5fold during UV-induced apoptosis. When cells are exposed to UV light to induce apoptosis, phosphatidylserine biosynthesis is stimulated 2fold in PSS II-expressing cells | Cricetulus griseus |
Organism | UniProt | Comment | Textmining |
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Cricetulus griseus | O08888 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PSSII | - |
Cricetulus griseus |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphatidylserine biosynthesis in Chinese hamster ovary cells increases 2.5fold during UV-induced apoptosis and is not reversed by caspase inhibitor, Z-VAD-FMK, i.e. benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone. Stimulation of synthesis is less specific for phosphatidylserine as similar levels of stimulation are observed for sphingomyelin biosynthesis. PSS I- , EC 2.7.8.8, or PSS II-expressing cells have higher basal levels of phosphatidylserine biosynthesis compared with vector control cells. When cells are exposed to UV light to induce apoptosis, phosphatidylserine biosynthesis is further stimulated 1.5- and 2fold in PSS I- and PSS II-expressing cells respectively. Cells overexpressing PSS I and II are actually resistant to UV-induced apoptosis | Cricetulus griseus |