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Literature summary for 2.7.8.27 extracted from

  • Hsiao, J.H.; Fu, Y.; Hill, A.F.; Halliday, G.M.; Kim, W.S.
    Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation (2013), PLoS ONE, 8, e74016.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
tricyclodecan-9-yl-xanthogenate i.e. D609 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a ceramide + a phosphatidylcholine Homo sapiens
-
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86VZ5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the enzyme SGMS1 expression, but not SGMS2 expression, is significantly elevated in the hippocampus of Alzheimer's disease brains, but not in the cerebellum Homo sapiens
-
cerebellum
-
Homo sapiens
-
hippocampus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a ceramide + a phosphatidylcholine
-
Homo sapiens a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
?
additional information sphingomyelin measurement via a four-step enzymatic process involving sphingomyelinase and histochemic detection Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
phosphatidylcholine:ceramide cholinephosphotransferase 1
-
Homo sapiens
SGMS
-
Homo sapiens
SGMS1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction inhibition of SGMS activity by siRNA transient transfection or by tricyclodecan-9-yl-xanthogenate (D609) significantly reduces the level of amyloid-beta peptide in a dose and time dependent manner. The decrease in amyloid-beta peptide level occurs without changes in amyloid precursor protein expression or cell viability Homo sapiens
physiological function enzyme SGMS activity impacts on amyloid precursor protein processing to produce amyloid-beta peptide and it seems to be a contributing factor in amyloid-beta peptide pathology associated with Alzheimer's disease. SGMS1 activity regulates amyloid precursor protein processing and not production Homo sapiens