Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tricyclodecan-9-yl-xanthogenate | i.e. D609 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a ceramide + a phosphatidylcholine | Homo sapiens | - |
a sphingomyelin + a 1,2-diacyl-sn-glycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86VZ5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | the enzyme SGMS1 expression, but not SGMS2 expression, is significantly elevated in the hippocampus of Alzheimer's disease brains, but not in the cerebellum | Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a ceramide + a phosphatidylcholine | - |
Homo sapiens | a sphingomyelin + a 1,2-diacyl-sn-glycerol | - |
? | |
additional information | sphingomyelin measurement via a four-step enzymatic process involving sphingomyelinase and histochemic detection | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylcholine:ceramide cholinephosphotransferase 1 | - |
Homo sapiens |
SGMS | - |
Homo sapiens |
SGMS1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of SGMS activity by siRNA transient transfection or by tricyclodecan-9-yl-xanthogenate (D609) significantly reduces the level of amyloid-beta peptide in a dose and time dependent manner. The decrease in amyloid-beta peptide level occurs without changes in amyloid precursor protein expression or cell viability | Homo sapiens |
physiological function | enzyme SGMS activity impacts on amyloid precursor protein processing to produce amyloid-beta peptide and it seems to be a contributing factor in amyloid-beta peptide pathology associated with Alzheimer's disease. SGMS1 activity regulates amyloid precursor protein processing and not production | Homo sapiens |