Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MEF cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + C6-ceramide | - |
Mus musculus | C6-sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMS | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | sphingomyelin synthase (SMS) deficiency promotes cell migration through a CXCL12/CXCR4-dependent signaling pathway involving extracellular signal-regulated kinase activation. In addition, SMS1/SMS2 double-knockout cells have heightened sensitivity to CXCL12. SMS deficiency facilitates relocalization of CXCR4 to lipid rafts, which form platforms for the regulation and transduction of receptor-mediated signaling. Furthermore, SMS deficiency potentiates CXCR4 dimerization, which is required for signal transduction | Mus musculus |
physiological function | sphingomyelin synthase-generated sphingomyelin is involed in the regulation of cell migration | Mus musculus |