Application | Comment | Organism |
---|---|---|
drug development | SMS is a target for drug design | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transient expression of Flag-tagged wild-type SMS2 and mutants in HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H285A | site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology | Homo sapiens |
H328A | site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology | Homo sapiens |
H332A | site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology | Homo sapiens |
S273A | site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology | Homo sapiens |
S283A | site-directed mutagenesis, inactive mutant with wild-type localization pattern, overview. The point mutation only influences SMS2 catalytic activity but not the enzyme topology | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | isozyme SMS1 | Homo sapiens | 5794 | - |
Golgi apparatus | isozyme SMS2 | Homo sapiens | 5794 | - |
plasma membrane | isozyme SMS2 | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | sphingomyelin synthase sits at the crossroads of sphingomyelin, ceramide, and diacylglycerol metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce sphingomyelin and diacylglycerol, thereby regulating lipid messengers which play a role in cell survival and apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86VZ5 | SMS1; isozyme SMS1 | - |
Homo sapiens | Q8NHU3 | SMS2; isozyme SMS2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alpha-phosphatidylcholine + NBD-C6-ceramide | i.e. N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide | Homo sapiens | ? | - |
? | |
additional information | sphingomyelin synthase sits at the crossroads of sphingomyelin, ceramide, and diacylglycerol metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce sphingomyelin and diacylglycerol, thereby regulating lipid messengers which play a role in cell survival and apoptosis | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | SMS isozyme domain structure and active site comformation, tertiary structure model by homology modeling, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
SMS1 | - |
Homo sapiens |
SMS2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |