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Literature summary for 2.7.8.27 extracted from

  • Li, Z.; Hailemariam, T.K.; Zhou, H.; Li, Y.; Duckworth, D.C.; Peake, D.A.; Zhang, Y.; Kuo, M.S.; Cao, G.; Jiang, X.C.
    Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization (2007), Biochim. Biophys. Acta, 1771, 1186-1194.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.27

Cloned(Commentary)

Cloned (Comment) Organism
SMS1 and SMS2 expression levels, quatitative determination by Real-time PCT analysis, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information downregulation of SMS in Huh7 cells by expression of siRNA, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
potassium tricyclodecan-9-yl-xanthogenate i.e. D609, decreases enzyme activity an sphingomyelin levels in different human cell lines in vivo Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens sphingomyelin plays a very important role both in cell membrane formation, inhibition of sphingomyelin synthase affects intracellular sphingomyelin accumulation and plasma membrane lipid organization, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes SMS1 and SMS2
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
Huh-7 cell a hepatoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alpha-phosphatidylcholine + N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide i.e. NBD-C6-ceramide Homo sapiens ?
-
 ?
additional information sphingomyelin plays a very important role both in cell membrane formation, inhibition of sphingomyelin synthase affects intracellular sphingomyelin accumulation and plasma membrane lipid organization, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SMS1
-
 Homo sapiens
SMS2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens