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Literature summary for 2.7.8.27 extracted from

  • Van der luit, A.H.; Budde, M.; Zerp, S.; Caan, W.; Klarenbeek, J.B.; Verheij, M.; van Blitterswijk, W.J.
    Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts (2007), Biochem. J., 401, 541-549.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene SMS1 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information S49AR cells show a defect in the synthesis of sphingomyelin and downregulated SMS1, phenotype, overview. Resistance to ALP can be mimicked by small interfering RNA-induced SMS1 suppression, resulting in sphingomyelin deficiency and blockage of raft-dependent internalization of ALP and induction of apoptosis, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information disturbance of cholesterol homoeostasis by 3-beta-[2-(diethylamino)-ethoxy]androst-5-en-17-one, i.e. U18666A, indirectly inhibits sphingomyelin biosynthesis, overview Mus musculus
tricyclodecan-9-yl-xanthogenate i.e. D609 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane SMS1 Mus musculus 139
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus SMS1 is located in the Golgi apparatus, where its two enzymatic products, sphingomyelin and diacylglycerol, play an important role in new lipid raft formation and secretory vesicle formation at the trans-Golgi network for transport to the plasma membrane, sphingomyelin synthesis through SMS1 depends on cholesterol homeostasis. S49AR cells are unable to synthesize sphingomyelin due to downregulated SMS1 expression ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 isozyme SMS1
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Source Tissue

Source Tissue Comment Organism Textmining
additional information no expression of SMS1 and SMS2 in alkyl-lysophospholipid-resistant S49AR mouse lymphoma cells Mus musculus
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S49 cell lymphoma cell line, expression of SMS1, not of SMS2 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SMS1 is located in the Golgi apparatus, where its two enzymatic products, sphingomyelin and diacylglycerol, play an important role in new lipid raft formation and secretory vesicle formation at the trans-Golgi network for transport to the plasma membrane, sphingomyelin synthesis through SMS1 depends on cholesterol homeostasis. S49AR cells are unable to synthesize sphingomyelin due to downregulated SMS1 expression Mus musculus ?
-
 ?
N-lauroyl-D-erythro-sphingosylphosphorylcholine + N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide i.e. lauroyl sphingomyelin and C6-NBD-ceramide Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
SM synthase 1
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 Mus musculus
SMS1
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 Mus musculus
sphingomyelin synthase 1
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 Mus musculus