Cloned (Comment) | Organism |
---|---|
stable overexpression of SMS1 in Jurkat cells leading to a 3.8fold increase in SMS activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of SMS1 in Jurkat cells leads to suppression of the production of dihydroceramides and dihydrosphingosine, and ceramide | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | photosensitizer Pc 4, PDT, induces inhibition of SMS in Jurkat cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi membrane | isozyme SMS1 | Homo sapiens | 139 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | SMS1 suppresses ceramide production and apoptosis post-photodamage | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme SMS1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | clone E6-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SMS1 suppresses ceramide production and apoptosis post-photodamage | Homo sapiens | ? | - |
? | |
phosphatidylcholine + C6-ceramide | - |
Homo sapiens | ? | - |
? | |
phosphatidylcholine + C6-NBD-ceramide | i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SMS1 | - |
Homo sapiens |
sphingomyelin synthase 1 | - |
Homo sapiens |