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Literature summary for 2.7.8.27 extracted from
- Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase (2001), Am. J. Physiol., 281, L98-L107.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ceramide | - |
Homo sapiens |  |
| sphingosine | - |
Homo sapiens | |
| tumor necrosis factor-alpha | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide + phosphatidylcholine | Homo sapiens | the enzyme restores homeostasis between sphingomyelin and ceramide pools | sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| NCI-H441 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ceramide + phosphatidylcholine | - |
Homo sapiens | sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? | |
| ceramide + phosphatidylcholine | the enzyme restores homeostasis between sphingomyelin and ceramide pools | Homo sapiens | sphingomyelin + 1,2-diacyl-sn-glycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC:ceramide phosphocholinetransferase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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