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Literature summary for 2.7.8.2 extracted from

  • Henneberry, A.L.; Wistow, G.; McMaster, C.R.
    Cloning, genomic organization, and characterization of a human cholinephosphotransferase (2000), J. Biol. Chem., 275, 29808-29815.
    View publication on PubMed
Search for more literature for 2.7.8.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Mg2+ inhibitory above 10 mM, activation below Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activation, 10fold more than Mn2+, preferred substrates in decreasing order, activation by Mg2+: di18:1-diacylglycerol, 16:0/22:6-diacylglycerol, 16:0/18:1-diacylglycerol, 18:0/20:4-diacylglycerol, di16:0-diacylglycerol Homo sapiens
Mn2+ activation, but much less than Mg2+, preferred substrates in decreasing order, activation by Mn2+: di10:0-diacylglycerol, 18:1/2:0-diacylglycerol, 16:0/22:6-diacylglycerol, di18:1-diacylglycerol, di16:0-diacylglycerol, di14:1-diacylglycerol, di16:1-diacylglycerol Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
 x * 39000, hCPT1, SDS-PAGE and deduced from gene sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WUD6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-choline + 1,2-diacylglycerol preferred substrates in decreasing order, activation by Mg2+: di18:1-diacylglycerol, 16:0/22:6-diacylglycerol, 16:0/18:1-diacylglycerol, 18:0/20:4-diacylglycerol, di16:0-diacylglycerol, preferred substrates in decreasing order, activation by Mn2+: di10:0-diacylglycerol, 18:1/2:0-diacylglycerol, 16:0/22:6-diacylglycerol, di18:1-diacylglycerol, di16:0-diacylglycerol, di14:1-diacylglycerol, di16:1-diacylglycerol Homo sapiens CMP + a phosphatidylcholine
-
 ?
additional information no substrates: 16:0(O)/2:0-diacylglycerol, 16:0(O)/20:4-diacylglycerol Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 39000, hCPT1, SDS-PAGE and deduced from gene sequence Homo sapiens