Literature summary for 2.7.8.17 extracted from

Kudo, M.; Bao, M.; D'Souza, A.; Ying, F.; Pan, H.; Roe, B.A.; Canfield, W.M.
The alpha- and beta-subunits of the human UDP-N-acetylglucosamine:lysosomal enzyme phosphotransferase are encoded by a single cDNA (2005), J. Biol. Chem., 280, 36141-36149.

Cloned(Commentary)

Cloned (Comment)	Organism
cloning of a single cDNA and gene that encodes a precursor of the alpha- and beta-subunits of human GlcNAc-phosphotransferase (gene symbol, GNPTAB). Transfection of the alpha/beta-subunits precursor cDNA with or without cotransfection of the regulatory gamma-subunitc DNA results in an increase in GlcNAc-phosphotransferase activity on low molecular weight substrate. This demonstrates that the alpha/beta-subunits precursor cDNA encodes the catalytic domain of the enzyme	Homo sapiens

Cloned (Comment)

Organism

cloning of a single cDNA and gene that encodes a precursor of the alpha- and beta-subunits of human GlcNAc-phosphotransferase (gene symbol, GNPTAB). Transfection of the alpha/beta-subunits precursor cDNA with or without cotransfection of the regulatory gamma-subunitc DNA results in an increase in GlcNAc-phosphotransferase activity on low molecular weight substrate. This demonstrates that the alpha/beta-subunits precursor cDNA encodes the catalytic domain of the enzyme

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme catalyzes modification of lysosomal enzymes with mannose 6-phosphate. This modification is catalyzed by UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase. The modified lysosomal enzymes are then targeted to the lysosome	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q3T906	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme catalyzes modification of lysosomal enzymes with mannose 6-phosphate. This modification is catalyzed by UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase. The modified lysosomal enzymes are then targeted to the lysosome	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
UDP-N-acetylglucosamine:lysosomal enzyme phosphotransferase	-	Homo sapiens