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Literature summary for 2.7.8.15 extracted from

  • Chandra, N.C.; Doody, M.B.; Bretthauer, R.K.
    Specific lipids enhance the activity of UDP-GlcNAc: dolichol phosphate GlcNAc-1-phosphate transferase in rat liver endoplasmic reticulum membrane vesicles (1991), Arch. Biochem. Biophys., 290, 345-354.
    View publication on PubMed
Search for more literature for 2.7.8.15

Activating Compound

Activating Compound Comment Organism Structure
cardiolipin stimulates activity of enzyme in endoplasmic membrane vesicles, due to better solubilization of the dolichol phosphate Rattus norvegicus
monogalactosyldiglyceride stimulates activity of enzyme in endoplasmic membrane vesicles Rattus norvegicus
phosphatidylethanolamine stimulates activity of enzyme in endoplasmic membrane vesicles Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Triton X-100 substrate protects from inhibition Rattus norvegicus
tunicamycin
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km-value for dolichyl phosphate: 0.005 mg/0.1 ml Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
 Rattus norvegicus UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
 with 0.5% Triton X-100 in the assay mixture Rattus norvegicus
60
-
 with either dioleoylphosphatidylethanolamine or cardiolipin in the assay mixture Rattus norvegicus