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Literature summary for 2.7.8.14 extracted from

  • Ishimoto, N.; Strominger, J.L.
    Polyribitol phosphate synthetase of Staphylococcus aureus (1966), J. Biol. Chem., 241, 639-650.
    View publication on PubMed
Search for more literature for 2.7.8.14

Inhibitors

Inhibitors Comment Organism Structure
CMP
-
 Staphylococcus aureus
Gentian violet
-
 Staphylococcus aureus
additional information no inhibition: penicillin G, staphcillin, alpha-aminobenzyl-penicillin, bacitracin Staphylococcus aureus
novobiocin
-
 Staphylococcus aureus
Ristocetin
-
 Staphylococcus aureus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 CDPribitol in presence of Mn2+ Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
particle-bound
-
 Staphylococcus aureus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ slight stimulation Staphylococcus aureus
Mg2+ Mn2+ or Mg2+ required: 10-30 mM Staphylococcus aureus
Mn2+ Mn2+ or Mg2+ required, optimal concentration: 10-30 mM Staphylococcus aureus
additional information no effect: Ni2+, Zn2+, Ca2+ Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDPribitol + (ribitol phosphate)n Staphylococcus aureus
-
 CMP + (ribitol phosphate)n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDPribitol + (ribitol phosphate)n
-
 Staphylococcus aureus CMP + (ribitol phosphate)n+1
-
 ?
CDPribitol + (ribitol phosphate)n no substrate: D-ribitol 5-phosphate, CDP-ribitol treated with diphosphatase, acid or alkali Staphylococcus aureus CMP + (ribitol phosphate)n+1
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 Tris-HCl buffer Staphylococcus aureus