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Literature summary for 2.7.8.13 extracted from

  • Moberg, A.; Zander Balderud, L.; Hansson, E.; Boyd, H.
    Assessing HTS performance using bioassay ontology: screening and analysis of a bacterial phospho-N-acetylmuramoyl-pentapeptide translocase campaign (2014), Assay Drug Dev. Technol., 12, 506-513.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
analysis the enzyme is an attractive antibacterial drug target involved in peptidoglycan synthesis Bacillus subtilis
synthesis the enzyme is an attractive antibacterial drug target involved in peptidoglycan synthesis Bacillus subtilis

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition at 2 mM Bacillus subtilis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis Q03521 gene mraY
-
Bacillus subtilis 168 Q03521 gene mraY
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information assay method development for high-throughput screening assays and metadata annotation, overview Bacillus subtilis ?
-
?
additional information assay method development for high-throughput screening assays and metadata annotation, overview Bacillus subtilis 168 ?
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
Bacillus subtilis UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
Bacillus subtilis 168 UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
?

Synonyms

Synonyms Comment Organism
MraY
-
Bacillus subtilis
phospho-N-acetylmuramoyl-pentapeptide translocase
-
Bacillus subtilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Bacillus subtilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Bacillus subtilis