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Literature summary for 2.7.8.13 extracted from
- Studies on bacterial cell wall inhibitors. X. Properties of phosph-N-acetylmuramoyl-pentapeptide-transferase in peptidoglycan synthesis of Bacillus megaterium and its inhibition by amphomycin (1982), J. Antibiot., 35, 1216-1221.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Amphomycin | - |
Priestia megaterium |  |
| Cs+ | - |
Priestia megaterium | |
| NH4+ | - |
Priestia megaterium | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.093 | - |
UDP-MurNAc-pentapeptide | pH 8.5, 25°C, enzyme is not purified | Priestia megaterium | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for maximal activation, optimum concentration 25 mM | Priestia megaterium | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-NAc-muramoyl-pentapeptide + acceptor | Priestia megaterium | - |
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | Priestia megaterium KM / ATCC 13632 | - |
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Priestia megaterium | - |
- |
- |
| Priestia megaterium KM / ATCC 13632 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP | - |
Priestia megaterium | UMP + [2H]UDP-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP | - |
Priestia megaterium KM / ATCC 13632 | UMP + [2H]UDP-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | - |
Priestia megaterium | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | - |
Priestia megaterium KM / ATCC 13632 | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Priestia megaterium |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9 | activity is significantly weaker at values below pH7.5 or over pH 9.0, about 40% of activity maximum at pH 6.5, about 80% of activity maximum at pH 9.0 | Priestia megaterium |
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