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Literature summary for 2.7.8.11 extracted from

  • Norman, R.A.; McAlister, M.S.; Murray-Rust, J.; Movahedzadeh, F.; Stoker, N.G.; McDonald, N.Q.
    Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis (2002), Structure, 10, 393-402.
    View publication on PubMed
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Application

Application Comment Organism
medicine enzymes involved in the PI biosynthetic pathway are potential antimycobacterial agents Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
tbINO, the coding sequence of ino1 amplified by PCR, cloned into expression vector pET-15b and overproduced in Escherichia coli BL21 (DE3) Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
bound to the cofactor NAD+, space group P42(1)2, cell dimensions a = 116.2, b = 116.2, c = 64.5 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + myo-inositol Mycobacterium tuberculosis
-
 CMP + phosphatidyl-1D-myo-inositol
-
 r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + myo-inositol
-
 Mycobacterium tuberculosis CMP + phosphatidyl-1D-myo-inositol
-
 r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mycobacterium tuberculosis