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Literature summary for 2.7.8.11 extracted from

  • Nikawa, J.; Yamashita, S.
    Phosphatidylinositol synthase from yeast (1997), Biochim. Biophys. Acta, 1348, 173-178.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100
-
Rattus norvegicus
Triton X-100 reaction is dependent on for maximum activity Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
-
Rattus norvegicus
disruption of the PIS locus in the genome is lethal Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
H114Q oligonucleotide-mediated site-directed mutagenesis, substitution of amino acid at position 114 from His (CAC) + Gln (CAA) results in a 200fold increase in Km of the enzyme for myo-inositol, making cells auxotrophic for myo-inositol Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
CDP-diacylglycerol ? Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
microsome
-
Saccharomyces cerevisiae
-
-
mitochondrial membrane outer mitochondrial membrane Saccharomyces cerevisiae 31966
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus
Mg2+
-
Saccharomyces cerevisiae
Mn2+
-
Rattus norvegicus
Mn2+
-
Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23610
-
primary translate deduced from the encoding gene, PIS Rattus norvegicus
24820
-
calculated molecular mass from the cloned PI synthase gene Saccharomyces cerevisiae
34000
-
-
Rattus norvegicus
34000
-
SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-diacylglycerol + myo-inositol Rattus norvegicus
-
CMP + phosphatidyl-1D-myo-inositol
-
r
CDP-diacylglycerol + myo-inositol Saccharomyces cerevisiae
-
CMP + phosphatidyl-1D-myo-inositol
-
r

Organism

Organism UniProt Comment Textmining
no activity in Escherichia coli
-
-
-
Rattus norvegicus
-
rat
-
Saccharomyces cerevisiae
-
yeast
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + myo-inositol
-
Rattus norvegicus CMP + phosphatidyl-1D-myo-inositol
-
r
CDP-diacylglycerol + myo-inositol
-
Saccharomyces cerevisiae CMP + phosphatidyl-1D-myo-inositol
-
r

Synonyms

Synonyms Comment Organism
PI synthase
-
Saccharomyces cerevisiae