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Literature summary for 2.7.8.11 extracted from
- Stereospecific synthesis and enzyme studies of CDP-diacylglycerols (1982), Biochim. Biophys. Acta, 712, 473-483.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | non-competitive inhibition | Cavia porcellus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
CDP-1-stearoyl-2-oleoylglycerol | pH 8.3, 37°C | Cavia porcellus | |
| 0.045 | - |
CDP-1-stearoyl-2-arachidonoylglycerol | pH 8.3, 37°C | Cavia porcellus | |
| 0.05 | - |
CDP-dipalmitoyl-sn-glycerol | pH 8.3, 37°C | Cavia porcellus | |
| 0.16 | - |
CDP-distearoylglycerol | pH 8.3, 37°C | Cavia porcellus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-diacylglycerol + myo-inositol | Cavia porcellus | - |
CMP + phosphatidyl-1D-myo-inositol | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
guinea pig | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CDP-1-arachidonoyl-2-stearoylglycerol + myo-inositol | 6% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + 1-arachidonoyl-2-stearoylphosphtidylinositol | - |
r | |
| CDP-1-stearoyl-2-arachidonoylglycerol + myo-inositol | 4% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + 1-stearoyl-2-arachidonoylphosphatidylinositol | - |
r | |
| CDP-1-stearoyl-2-oleoylglycerol + myo-inositol | - |
Cavia porcellus | CMP + 1-stearoyl-2-oleoylphosphatidylinositol | - |
r | |
| CDP-diacylglycerol + myo-inositol | - |
Cavia porcellus | CMP + phosphatidyl-1D-myo-inositol | - |
r | |
| CDP-diarachidonoylglycerol + myo-inositol | 9% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + diarachidonoylphosphatidylinositol | - |
r | |
| CDP-dipalmitoyl-sn-glycerol + myo-inositol | - |
Cavia porcellus | CMP + dipalmitoylphosphatidylinositol | - |
? | |
| CDP-distearoylglycerol + myo-inositol | 38% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + distearoylphosphatidylinositol | - |
r | |
| CDPdipalmitoyl-sn-glycerol + myo-inositol | 70% of the activity with CDP-1-stearoyl-2-oleoylglycerol | Cavia porcellus | CMP + dipalmitoylphosphatidylinositol | - |
r | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
AMP | pH 8.3, 37°C | Cavia porcellus | |
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