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Literature summary for 2.7.7.9 extracted from

  • Chacko, C.M.; McCrone, L.; Nadler, H.L.
    Uridine diphosphoglucose pyrophosphorylase and uridine diphosphogalactose pyrophosphorylase in human skin fibroblasts derived from normal and galactosemic individuals (1972), Biochim. Biophys. Acta, 268, 113-120.
    View publication on PubMed
Search for more literature for 2.7.7.9

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
 UDP-glucose non-galactosemic phenotype, pH 7.8, 37°C Homo sapiens
0.18
-
 diphosphate non-galactosemic phenotype, pH 7.8, 37°C Homo sapiens
0.18
-
 UDP-glucose galactosemic phenotype, pH 7.8, 37°C Homo sapiens
0.2
-
 diphosphate galactosemic phenotype, pH 7.8, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast from normal and galactosemic individuals Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UTP + alpha-D-glucose 1-phosphate
-
 Homo sapiens diphosphate + UDP-glucose
-
 r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 15 min, about 10% or 25% loss of activity of enzymes from normal or galactosemic individuals, respectively Homo sapiens
56
-
 t1/2: 4 min Homo sapiens
56
-
 15 min: inactivation Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3 8.6 broad Homo sapiens