Cloned (Comment) | Organism |
---|---|
- |
Chandipura virus |
Protein Variants | Comment | Organism |
---|---|---|
H1217A | mutant is completely inactive in RNA capping | Chandipura virus |
H1226A | no loss of activity | Chandipura virus |
R1211A | mutant is completely inactive in RNA capping | Chandipura virus |
R1218A | mutant is completely inactive in RNA capping | Chandipura virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chandipura virus | P13179 | - |
- |
Chandipura virus I653514 | P13179 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-triphospho-mRNA + GDP | - |
Chandipura virus | diphosphate + guanosine 5'-triphospho-mRNA | - |
? | |
5'-triphospho-mRNA + GDP | - |
Chandipura virus I653514 | diphosphate + guanosine 5'-triphospho-mRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNA-directed RNA polymerase L | - |
Chandipura virus |
General Information | Comment | Organism |
---|---|---|
physiological function | RNA polymerase L protein shows RNA:GDP polyribonucleotidyltransferase activity, which transfers the 5'-monophosphorylated viral mRNA start sequence to GDP to produce a capped RNA. The conserved HR motif in the L protein is essential for the this activity. L protein forms two distinct SDS-resistant complexes with the mRNA and leader RNA start sequences, mutations in the HR motif significantly reduce the formation of the former complex, but not the latter complex | Chandipura virus |