Literature summary for 2.7.7.86 extracted from

Wang, J.; Chu, B.; Du, L.; Han, Y.; Zhang, X.; Fan, S.; Wang, Y.; Yang, G.
Molecular cloning and functional characterization of porcine cyclic GMP-AMP synthase (2015), Mol. Immunol., 65, 436-445.

Search for more literature for 2.7.7.86

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Sus scrofa	5829	-
endoplasmic reticulum	membrane of endoplasmic reticulum	Sus scrofa	5783	-

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	I3LM39	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
duodenum	mRNA is abundant in the spleen, duodenum, jejunum, and ileum	Sus scrofa	-
ileum	mRNA is abundant in the spleen, duodenum, jejunum, and ileum	Sus scrofa	-
jejunum	mRNA is abundant in the spleen, duodenum, jejunum, and ileum	Sus scrofa	-
PK-15 cell	-	Sus scrofa	-
spleen	mRNA is abundant in the spleen, duodenum, jejunum, and ileum	Sus scrofa	-

General Information

General Information	Comment	Organism
physiological function	the overexpression of wild-type cGAS in porcine kidney epithelial cells, but not its catalytically inactive mutants, induces IFN-beta expression, which is dependent on STING and IRF3. The downregulation of cGAS by RNAi markedly reduces IFN-beta expression after pseudorabies virus infection or poly(dA:dT) transfection	Sus scrofa

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Release 2023.1 (January 2023)