Literature summary for 2.7.7.86 extracted from

Wang, Y.; Su, G.H.; Zhang, F.; Chu, J.X.; Wang, Y.S.
Cyclic GMP-AMP synthase is required for cell proliferation and inflammatory responses in rheumatoid arthritis synoviocytes (2015), Mediators Inflamm., 2015, 192329.

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Application

Application	Comment	Organism
medicine	cGAS activates the AKT and ERK pathways to promote the inflammatory response of rheumatoid arthritis fibroblast-like synoviocytes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N884	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
synoviocyte	rheumatoid arthritis synoviocyte	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	cGAS is overexpressed in rheumatoid arthritis fibroblast-like synoviocytes compared with osteoarthritis fibroblast-like synoviocytes. TNFalpha stimulation induces cGAS expression in rheumatoid arthritis fibroblast-like synoviocytes. Overexpression of cGAS promotes the proliferation and knockdown of cGAS inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes. cGAS overexpression enhances the production of proinflammatory cytokines and matrix metalloproteinases as well as AKT and ERK phosphorylation in TNFalpha-stimulated fibroblast-like synoviocytes. In contrast, cGAS silencing inhibits production of proinflammatory cytokines and matrix metalloproteinases as well as AKT and ERK phosphorylation in TNFalpha-stimulated fibroblast-like synoviocytes	Homo sapiens

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Release 2023.1 (January 2023)