Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | upon infection with Chlamydia trachomatis cGAS localizes in punctate regions on the cytosolic side of the chlamydial inclusion membrane in association with stimulator of genes STING | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N884 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | cGAS is required for IFN-beta expression during chlamydial infection in multiple cell types. Although infected cells deficient for STING or cGAS alone fail to induce IFN-beta, coculture of cells depleted for either STING or cGAS rescues IFN-beta expression. Cyclic GMP-AMP produced in infected cGAS(+)STING(-) cells can migrate into adjacent cells via gap junctions to function in trans in cGAS(-)STING(+) cells | Homo sapiens |