Application | Comment | Organism |
---|---|---|
medicine | complete interferon IFN-beta induction by live Neisseria gonorrhoeae depends on both cGAS and toll-like receptor TLR4. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS-/- and TLR4-/- cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N884 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | type I interferon induction by Neisseria gonorrhoeae infection Is dependent on cGAS, but not PYHIN family member IFI16. Complete activation of IFN-beta by Neisseria gonorrhoeae infection is an additive effect of both cGAS/stimulator of IFN genes STING and toll-like receptor TLR4 pathways. cGAMP is induced after GC infection and GC DNA transfection | Homo sapiens |