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Literature summary for 2.7.7.86 extracted from

  • Gao, D.; Wu, J.; Wu, Y.; Du, F.; Aroh, C.; Yan, N.; Sun, L.; Chen, Z.
    Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses (2013), Science, 341, 903-906.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.86

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Homo sapiens
-
 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP
-
 Homo sapiens 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Synonyms

Synonyms Comment Organism
cGAS
-
 Homo sapiens
cyclic GMP-AMP synthase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockout or knockdown of the enzyme blocks cytokine induction by HIV, murine leukemia virus, and simian immunodeficiency virus. cGAS mutant cell lines fail to activate IRF3 in response to HT-DNA transfection or HSV-1 infection Homo sapiens
physiological function the enzyme is an innate immune sensor of HIV and other retroviruses. The enzyme binds to and activates the adaptor protein STING to induce type I interferons and other cytokines Homo sapiens