Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Rosetta2 (DE3) cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method, using 18% (w/v) PEG3350, 0.2 M ammonium nitrate, 0.5 M NaCl, and 0.02 mM CYMAL-7 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | Homo sapiens | - |
2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N884 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography, HiTrap heparin column chromatography, and Superdex 200 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GTP | - |
Homo sapiens | 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGAS | - |
Homo sapiens |
cyclic GMP-AMP synthase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme induces the activation of STING by producing cGAMP from GTP and ATP | Homo sapiens |