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Literature summary for 2.7.7.86 extracted from

  • Zhang, X.; Shi, H.; Wu, J.; Zhang, X.; Sun, L.; Chen, C.; Chen, Z.J.
    Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING (2013), Mol. Cell, 51, 226-235.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Homo sapiens
-
2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N884
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP
-
Homo sapiens 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
?

Synonyms

Synonyms Comment Organism
cGAMP synthase
-
Homo sapiens
cGAS
-
Homo sapiens

General Information

General Information Comment Organism
physiological function cGAMP synthase catalyzes the production of cGAMP that in turn serves as a second messenger to activate innate immune responses Homo sapiens