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Literature summary for 2.7.7.86 extracted from

  • Gao, P.; Ascano, M.; Wu, Y.; Barchet, W.; Gaffney, B.L.; Zillinger, T.; Serganov, A.A.; Liu, Y.; Jones, R.A.; Hartmann, G.; Tuschl, T.; Patel, D.J.
    Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase (2013), Cell, 153, 1094-1107.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
free enzyme or bound to a 16 base pair complementary double stranded DNA and ATP Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Mus musculus
Mn2+ required for activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Mus musculus over 78% conversion within 40 min 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C6L5
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP over 78% conversion within 40 min Mus musculus 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
?

Synonyms

Synonyms Comment Organism
cGAMP synthase
-
Mus musculus
cGAS
-
Mus musculus