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Literature summary for 2.7.7.80 extracted from

  • Matthies, A.; Nimtz, M.; Leimkühler, S.
    Molybdenum cofactor biosynthesis in humans: Identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry (2005), Biochemistry, 44, 7912-7920.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly Homo sapiens
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diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95396
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly
-
Homo sapiens diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP
-
?

Synonyms

Synonyms Comment Organism
MOCS3
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Homo sapiens

General Information

General Information Comment Organism
additional information the human MOCS3 protein contains an N-terminal domain similar to the Escherichia coli MoeB protein. This N-terminal MoeB-like domain is active in catalyzing the adenylyltransferase activity, and C239 of the N-terminal MoeB-like domain of MOCS3 is most likely involved in the sulfur transfer mechanism of the persulfide sulfur to MOCS2A Homo sapiens
physiological function MOCS3 catalyzes both the adenylation and the subsequent generation of a thiocarboxylate group at the C-terminus of the smaller subunit of molybdopterin synthase during molybdenum cofactor biosynthesis in humans. Similar to ubiquitin activating enzymes, the N-terminus of MOCS3 is expected to activate the C-terminal glycine of MOCS2A to form an acyl adenylate. Subsequently, the C-terminal rhodanese-like domain of MOCS3 acts as a direct sulfur donor for the formation of a thiocarboxylate group on MOCS2A. The MOCS2A thiocarboxylate sulfur is used for the generation of the dithiolene moiety of molybdopterin which coordinates the molybdenum atom in the molybdenum cofactor Homo sapiens