Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly | Homo sapiens | - |
diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95396 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly | - |
Homo sapiens | diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MOCS3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | the human MOCS3 protein contains an N-terminal domain similar to the Escherichia coli MoeB protein. This N-terminal MoeB-like domain is active in catalyzing the adenylyltransferase activity, and C239 of the N-terminal MoeB-like domain of MOCS3 is most likely involved in the sulfur transfer mechanism of the persulfide sulfur to MOCS2A | Homo sapiens |
physiological function | MOCS3 catalyzes both the adenylation and the subsequent generation of a thiocarboxylate group at the C-terminus of the smaller subunit of molybdopterin synthase during molybdenum cofactor biosynthesis in humans. Similar to ubiquitin activating enzymes, the N-terminus of MOCS3 is expected to activate the C-terminal glycine of MOCS2A to form an acyl adenylate. Subsequently, the C-terminal rhodanese-like domain of MOCS3 acts as a direct sulfur donor for the formation of a thiocarboxylate group on MOCS2A. The MOCS2A thiocarboxylate sulfur is used for the generation of the dithiolene moiety of molybdopterin which coordinates the molybdenum atom in the molybdenum cofactor | Homo sapiens |