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Literature summary for 2.7.7.8 extracted from

  • Wu, J.; Li, Z.
    Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress (2008), Biochem. Biophys. Res. Commun., 372, 288-292.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.8

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of polynucleotide phosphorylase in HeLa cells under oxidative stress conditions reduces RNA oxidation and increases cell viability against H2O2 insult. Knock-down of enzyme decreases viability and increases 8-oxoguanosine levels in cells exposed to H2O2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens polynucleotide phosphorylase is involved in protecting cells and limiting damaged RNA under oxidative conditions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information polynucleotide phosphorylase is involved in protecting cells and limiting damaged RNA under oxidative conditions Homo sapiens ?
-
 ?