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Literature summary for 2.7.7.72 extracted from

  • Shikha, S.; Schneider, A.
    The single CCA-adding enzyme of T. brucei has distinct functions in the cytosol and in mitochondria (2020), J. Biol. Chem., 295, 6138-6150 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.72

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Trypanosoma brucei brucei 5829
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mitochondrion a fraction of CAE is imported into mitochondria Trypanosoma brucei brucei 5739
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei brucei
-
-
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Trypanosoma brucei brucei 927/4 GUTat10.1
-
-
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Synonyms

Synonyms Comment Organism
CaE
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 Trypanosoma brucei brucei
Tb927.9.8780
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 Trypanosoma brucei brucei

General Information

General Information Comment Organism
physiological function knockdown of CAE results in the accumulation of truncated tRNAs, abolishes translation, and inhibits both total and mitochondrial CCA-adding activities. Mitochondrially localized tRNAs are much less affected by the CAE ablation than the other tRNAs. The N-terminal 10 amino acids of CAE are dispensable for its activity and mitochondrial localization and deletion of 10 further amino acids abolishes both. A growth arrest caused by the CAE knockdown is rescued by the expression of the cytosolic isoform of yeast CAE Trypanosoma brucei brucei