Literature summary for 2.7.7.7 extracted from

Genna, V.; Vidossich, P.; Ippoliti, E.; Carloni, P.; De Vivo, M.
A self-activated mechanism for nucleic acid polymerization catalyzed by DNA/RNA polymerases (2016), J. Am. Chem. Soc., 138, 14592-14598 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y253	-	-

Synonyms

Synonyms	Comment	Organism
DNA polymerase eta	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	a self-activated mechanism for efficient polymerase catalysis is proposed, which is based on the identification of an evolutionary convergence to preserve a key enzymatic structural element in all the available X-ray structures of DNA/RNA polymerases from all domains of life	Homo sapiens
physiological function	the enzyme is involved in repairing damaged DNA	Homo sapiens

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Release 2023.1 (January 2023)