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Literature summary for 2.7.7.7 extracted from

  • Xue, Q.; Zhong, M.; Liu, B.; Tang, Y.; Wei, Z.; Guengerich, F.; Zhang, H.
    Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA polymerase eta (2016), Biochimie, 121, 161-169 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Cloned(Commentary)

Cloned (Comment) Organism
catalytic core of DNA polymerase eta (residues 1-513) Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Saccharomyces cerevisiae the catalytic core of yeast DNA polymerase eta prefers to incorporate dCTP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (damage produced by reactive oxygen species in DNA). dCTP incorporation is slower than the dissociation of the polymerase from DNA. 57% of the extension products beyond the 7,8-dihydro-8-oxo-2'-deoxyguanosine are the products corresponding to the correct incorporation (C) and 43% corresponding to dATP misincorporation diphosphate + DNAn+1
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 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Saccharomyces cerevisiae YJM789 the catalytic core of yeast DNA polymerase eta prefers to incorporate dCTP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (damage produced by reactive oxygen species in DNA). dCTP incorporation is slower than the dissociation of the polymerase from DNA. 57% of the extension products beyond the 7,8-dihydro-8-oxo-2'-deoxyguanosine are the products corresponding to the correct incorporation (C) and 43% corresponding to dATP misincorporation diphosphate + DNAn+1
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae A6ZZ16
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Saccharomyces cerevisiae YJM789 A6ZZ16
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-

Purification (Commentary)

Purification (Comment) Organism
catalytic core of DNA polymerase eta (residues 1-513) Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn the catalytic core of yeast DNA polymerase eta prefers to incorporate dCTP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (damage produced by reactive oxygen species in DNA). dCTP incorporation is slower than the dissociation of the polymerase from DNA. 57% of the extension products beyond the 7,8-dihydro-8-oxo-2'-deoxyguanosine are the products corresponding to the correct incorporation (C) and 43% corresponding to dATP misincorporation Saccharomyces cerevisiae diphosphate + DNAn+1
-
 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn the catalytic core of yeast DNA polymerase eta prefers to incorporate dCTP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (damage produced by reactive oxygen species in DNA). dCTP incorporation is slower than the dissociation of the polymerase from DNA. 57% of the extension products beyond the 7,8-dihydro-8-oxo-2'-deoxyguanosine are the products corresponding to the correct incorporation (C) and 43% corresponding to dATP misincorporation Saccharomyces cerevisiae YJM789 diphosphate + DNAn+1
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 ?

Synonyms

Synonyms Comment Organism
DNA Pol eta
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 Saccharomyces cerevisiae
RAD30
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 Saccharomyces cerevisiae