Literature summary for 2.7.7.7 extracted from

Matsui, E.; Urushibata, Y.; Abe, J.; Matsui, I.
Serial intermediates with a 1 nt 3'-flap and 5' variable-length flaps are formed by cooperative functioning of Pyrococcus horikoshii FEN-1 with either B or D DNA polymerases (2014), Extremophiles, 18, 415-427 .

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Organism

Organism	UniProt	Comment	Textmining
Pyrococcus horikoshii	O57863 and O57861	O57863: DNA polymerase II small subunit, gene name polB, ordered locus name: PH0123, O57861: DNA polymerase II large subunit, gene name polC, ordered locus name: PH0121	-
Pyrococcus horikoshii OT-3	O57863 and O57861	O57863: DNA polymerase II small subunit, gene name polB, ordered locus name: PH0123, O57861: DNA polymerase II large subunit, gene name polC, ordered locus name: PH0121	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	FEN-1 has both 5'-flap endonuclease and 5'3' exonuclease activities, FEN-1 activity is elevated by the presence of a 1 nucleotide expansion at the 3' end in the upstream primer of substrates called: structures with a 1 nt 3'-flap, which appear to be the most preferable substrates for FEN-1. Serial intermediates with a 1 nt 3'-flap and 5' variable-length flaps are formed by cooperative functioning of Pyrococcus horikoshii FEN-1 with either B or D DNA polymerases	Pyrococcus horikoshii	?	-	?
additional information	FEN-1 has both 5'-flap endonuclease and 5'3' exonuclease activities, FEN-1 activity is elevated by the presence of a 1 nucleotide expansion at the 3' end in the upstream primer of substrates called: structures with a 1 nt 3'-flap, which appear to be the most preferable substrates for FEN-1. Serial intermediates with a 1 nt 3'-flap and 5' variable-length flaps are formed by cooperative functioning of Pyrococcus horikoshii FEN-1 with either B or D DNA polymerases	Pyrococcus horikoshii OT-3	?	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerases D	-	Pyrococcus horikoshii
phPol D	-	Pyrococcus horikoshii

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Release 2023.1 (January 2023)