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Literature summary for 2.7.7.7 extracted from

  • Rajao, M.A.; Passos-Silva, D.G.; DaRocha, W.D.; Franco, G.R.; Macedo, A.M.; Pena, S.D.; Teixeira, S.M.; Machado, C.R.
    DNA polymerase kappa from Trypanosoma cruzi localizes to the mitochondria, bypasses 8-oxoguanine lesions and performs DNA synthesis in a recombination intermediate (2009), Mol. Microbiol., 71, 185-197.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Trypanosoma cruzi 5739
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Trypanosoma cruzi diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase kappa
-
 Trypanosoma cruzi
Polkappa
-
 Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function Polkappa efficiently bypasses 8-oxoguanine lesions, Polkappa increases Trypanosoma cruzi resistance to high doses of gamma irradiation and zeocin and can catalyse DNA synthesis within recombination intermediates Trypanosoma cruzi