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Literature summary for 2.7.7.7 extracted from

  • Fowler, J.D.; Brown, J.A.; Johnson, K.A.; Suo, Z.
    Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase (2008), J. Biol. Chem., 283, 15339-15348.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Protein Variants

Protein Variants Comment Organism
E200A exonuclease-deficient mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
gemcitabine i.e. 2'-deoxy-2',2'-difluorocytidine, when gemcitabine is encountered as a template base DNA polymerase gamma pauses at the lesion and one downstream position but eventually elongates the primer to full-length product, these pauses are because of a 1000fold decrease in nucleotide incorporation efficiency Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?
additional information the excision of the matched 3'-monophosphorylated form of 2'-deoxy-2',2'-difluorocytidine moiety by the wild type pol gamma is 55fold slower than the excision of matched 3'-dCMP Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase gamma
-
 Homo sapiens
Pol gamma
-
 Homo sapiens