Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UNA4 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel affinity column chromatography and SP column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | DNA polymerase iota preferentially misincorporates nucleotides opposite thymines and halts replication at T bases | Homo sapiens | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase iota | - |
Homo sapiens |
poliota | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | poliota uniquely replicates DNA with a constrained active site, creating shorter C1'-C1' strand distances, with the finger domain projecting the template base out towards the solvent-accessible major groove and stabilizing a mismatched G base through H-bonding | Homo sapiens |