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BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Martomo, S.A.; Saribasak, H.; Yokoi, M.; Hanaoka, F.; Gearhart, P.J.
    Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes (2008), DNA Repair, 7, 1603-1608.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Mus musculus
-
spleen
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Mus musculus diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase eta
-
Mus musculus
DNA polymerase theta
-
Mus musculus
Pol eta
-
Mus musculus
Pol theta
-
Mus musculus

General Information

General Information Comment Organism
malfunction class switch recombination is normal in mice deficient for pols theta and eta Mus musculus
physiological function pol theta has no major involvement in somatic hypermutation Mus musculus